ENTRY       EC 3.4.23.15
NAME        Renin
            Angiotensin-forming enzyme
            Angioteninogenase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aspartic endopeptidases
REACTION    Cleaves of Leu+ bond in angiotensinogen to generate angiotensin I
SUBSTRATE   Angiotensinogen
            H2O
PRODUCT     Angiotensin I
COMMENT     Formed from prorenin in plasma and kidney.  Formerly EC 3.4.99.19.
DISEASE     MIM: 179820  Renin; [Hyperproreninemia] (3)
MOTIF       PS: PS00141  [LIVMFGAC]-[LIVMTADN]-[LIVFSA]-D-[ST]-G-[STAV]-
                         [STAPDENQ]-x-[LIVMFSTNC]-x-[LIVMFGTA]
GENES       HSA: REN
STRUCTURES  PDB: 2REN  1BBS  1SMR  1RNE  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.23.15
            WIT (What Is There) Metabolic Reconstruction: 3.4.23.15
            SCOP (Structural Classificaion of Proteins): 3.4.23.15
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