ENTRY       EC 3.4.22.6
NAME        Chymopapain
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Cysteine endopeptidases
REACTION    Hydrolysis of proteins with broad specificity for peptide bonds,
            with preference for a residue bearing a large hydrophobic
            sidechain at the P2 position.  Does not accept Val at P1'
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COMMENT     The major endopeptidase of papaya (Carica papaya) latex.  It has
            multiple chromatographic forms.  Formerly EC 3.4.4.11.
MOTIF       PS: PS00139  Q-x(3)-[GE]-x-C-[YW]-x(2)-[STAGC]-[STAGCV]
            PS: PS00639  [LIVMGSTAN]-x-H-[GSACE]-[LIVM]-x-[LIVMAT](2)-G-x-
                         [GSADNH]
            PS: PS00640  [FYCH]-[WI]-[LIVT]-x-[KRQAG]-N-[ST]-W-x(3)-[FYW]-G-
                         x(2)-G-[LFYW]-[LIVMFYG]-x-[LIVMF]
STRUCTURES  PDB: 1PCI  1YAL  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.22.6
            WIT (What Is There) Metabolic Reconstruction: 3.4.22.6
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