ENTRY       EC 3.4.22.35
NAME        Histolysain
            Histolysin
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Cysteine endopeptidases
REACTION    Hydrolysis of proteins, including basement membrane collagen and
            azocasein. Preferential cleavage: Arg-Arg+ in small molecule
            substrates including Z-Arg-Arg+NHMec.
SUBSTRATE   Protein
            Peptide
            H2O
            Collagen
            Azocasein
PRODUCT     Protein
            Peptide
COMMENT     From trotozoan, Entamoeba histolytica. A homologue of papain.
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.22.35
            WIT (What Is There) Metabolic Reconstruction: 3.4.22.35
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