ENTRY       EC 3.4.22.33
NAME        Fruit bromelain
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Cysteine endopeptidases
REACTION    Hydrolysis of proteins with broad specificity for peptide bonds.
            Bz-Phe-Val-Arg+NHMec is a good synthetic substrate, but there is
            no action on Z-Arg-Arg-NHMec (cf. stem bromelain).
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COMMENT     From the pineapple plant, Ananas comosus. Scarcely inhibited by
            chicken cystatin.  Another cysteine endopeptidase, with similar
            action on small molecule substrates, pinguinain (formerly
            EC 3.4.99.18), is obtained from the related plant, Bromelia
            pinguin, but pinguinain differs from fruit bromelain in being
            inhibited by chicken cystatin. Formerly EC 3.4.22.5 and
            included in EC 3.4.22.4.
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.22.33
            WIT (What Is There) Metabolic Reconstruction: 3.4.22.33
///