ENTRY       EC 3.4.22.3
NAME        Ficain
            Ficin
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Cysteine endopeptidases
REACTION    Hydrolysis of proteins with broad specificity for peptide bonds,
            with preference for a residue bearing a large hydrophobic
            sidechain at the P2 position.  Does not accept Val at P1'.
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COMMENT     The major proteolytic component of the latex of fig, Ficus
            glabrata. Cysteine endopeptidases with similar properties are
            present in other members of the large genus Ficus. Formerly
            EC 3.4.4.12.
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.22.3
            WIT (What Is There) Metabolic Reconstruction: 3.4.22.3
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