ENTRY       EC 3.4.22.28
NAME        Picornain 3C
            Picornavirus endopeptidase 3C
            Poliovirus protease 3C
            Rhinovirus protease 3C
            Foot-and-mouth protease 3C
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Cysteine endopeptidases
REACTION    Selective cleavage of Gln+Gly bond in the poliovirus polyprotein.
            In other picornavirus reactions Glu may be substituted for Gln,
            and Ser or Thr for Gly.
SUBSTRATE   Poliovirus polyprotein
            H2O
PRODUCT     Protein
COMMENT     From entero-, rhino-, aphto- and cardioviruses. Larger than the
            homologous virus picornain 2A, but not a homologue of papain.
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.22.28
            WIT (What Is There) Metabolic Reconstruction: 3.4.22.28
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