ENTRY       EC 3.4.22.27
NAME        Cathepsin S
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Cysteine endopeptidases
REACTION    Similar to cathepsin L, but with much less activity on
            Z-Phe-Arg+NHMec, and more activity on the Z-Val-Val-Arg+ compound
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COMMENT     A lysosomal cysteine endopeptidase that is unusual amongst such
            enzymes for its stability to neutral pH.
DISEASE     MIM: 116845  Cathepsin S
MOTIF       PS: PS00139  Q-x(3)-[GE]-x-C-[YW]-x(2)-[STAGC]-[STAGCV]
            PS: PS00639  [LIVMGSTAN]-x-H-[GSACE]-[LIVM]-x-[LIVMAT](2)-G-x-
                         [GSADNH]
            PS: PS00640  [FYCH]-[WI]-[LIVT]-x-[KRQAG]-N-[ST]-W-x(3)-[FYW]-G-
                         x(2)-G-[LFYW]-[LIVMFYG]-x-[LIVMF]
GENES       HSA: CTSS(Hs.81356)
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.22.27
            WIT (What Is There) Metabolic Reconstruction: 3.4.22.27
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