ENTRY       EC 3.4.22.25
NAME        Glycyl endopeptidase
            Papaya peptidase B
            Papaya proteinase IV
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Cysteine endopeptidases
REACTION    Preferential cleavage: Gly+, in proteins and small molecule
            substrates.
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COMMENT     From the papaya plant, Carica papaya. Not inhibited by chicken
            cystatin, unlike most other homologues of papain.
MOTIF       PS: PS00139  Q-x(3)-[GE]-x-C-[YW]-x(2)-[STAGC]-[STAGCV]
            PS: PS00639  [LIVMGSTAN]-x-H-[GSACE]-[LIVM]-x-[LIVMAT](2)-G-x-
                         [GSADNH]
            PS: PS00640  [FYCH]-[WI]-[LIVT]-x-[KRQAG]-N-[ST]-W-x(3)-[FYW]-G-
                         x(2)-G-[LFYW]-[LIVMFYG]-x-[LIVMF]
STRUCTURES  PDB: 1GEC  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.22.25
            WIT (What Is There) Metabolic Reconstruction: 3.4.22.25
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