ENTRY       EC 3.4.22.16
NAME        Cathepsin H
            Cathepsin B3
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Cysteine endopeptidases
REACTION    Hydrolysis of proteins, acting as an aminopeptidase (notably,
            cleaving Arg+ bonds) as well as an endopeptidase
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COMMENT     Peptide
COMMENT     Present in lysosomes of most mammalian cells.
DISEASE     MIM: 116820  Cathepsin H
MOTIF       PS: PS00139  Q-x(3)-[GE]-x-C-[YW]-x(2)-[STAGC]-[STAGCV]
            PS: PS00639  [LIVMGSTAN]-x-H-[GSACE]-[LIVM]-x-[LIVMAT](2)-G-x-
                         [GSADNH]
            PS: PS00640  [FYCH]-[WI]-[LIVT]-x-[KRQAG]-N-[ST]-W-x(3)-[FYW]-G-
                         x(2)-G-[LFYW]-[LIVMFYG]-x-[LIVMF]
GENES       HSA: CTSH(CPSB)
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.22.16
            WIT (What Is There) Metabolic Reconstruction: 3.4.22.16
///