ENTRY       EC 3.4.22.15
NAME        Cathepsin L
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Cysteine endopeptidases
REACTION    Hydrolysis of proteins with broad specificity for peptide bonds,
            with preference for a residue bearing a large hydrophobic
            sidechain at the P2 position.  Does not accept Val at P1'.
            As compared to cathepsin B, cathepsin L exhibits higher activity
            towards protein substrates, but has little activity on
            Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
INHIBITOR   Leupeptin
            Z-Phe-Phe-CHN2
            E-64
COMMENT     A lysosomal enzyme that is readily inhibited by the deazomethane
            inhibitor Z-Phe-Phe-CHN2 or the epoxide inhibitor E-64.
DISEASE     MIM: 116880  Cathepsin L
MOTIF       PS: PS00139  Q-x(3)-[GE]-x-C-[YW]-x(2)-[STAGC]-[STAGCV]
            PS: PS00639  [LIVMGSTAN]-x-H-[GSACE]-[LIVM]-x-[LIVMAT](2)-G-x-
                         [GSADNH]
            PS: PS00640  [FYCH]-[WI]-[LIVT]-x-[KRQAG]-N-[ST]-W-x(3)-[FYW]-G-
                         x(2)-G-[LFYW]-[LIVMFYG]-x-[LIVMF]
GENES       HSA: CTSL(Hs.78056)
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.22.15
            WIT (What Is There) Metabolic Reconstruction: 3.4.22.15
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