ENTRY       EC 3.4.22.14
NAME        Actinidain
            Actinidin
            Actinidia anionic protease
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Cysteine endopeptidases
REACTION    Hydrolysis of proteins with broad specificity for peptide bonds,
            with preference for a residue bearing a large hydrophobic
            sidechain at the P2 position.  Does not accept Val at P1'
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COMMENT     From the kiwi fruit or Chinese gooseberry (Actinidia chinensis).
MOTIF       PS: PS00139  Q-x(3)-[GE]-x-C-[YW]-x(2)-[STAGC]-[STAGCV]
            PS: PS00639  [LIVMGSTAN]-x-H-[GSACE]-[LIVM]-x-[LIVMAT](2)-G-x-
                         [GSADNH]
            PS: PS00640  [FYCH]-[WI]-[LIVT]-x-[KRQAG]-N-[ST]-W-x(3)-[FYW]-G-
                         x(2)-G-[LFYW]-[LIVMFYG]-x-[LIVMF]
STRUCTURES  PDB: 1AEC  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.22.14
            WIT (What Is There) Metabolic Reconstruction: 3.4.22.14
            SCOP (Structural Classificaion of Proteins): 3.4.22.14
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