ENTRY       EC 3.4.22.1
NAME        Cathepsin B
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Cysteine endopeptidases
REACTION    Hydrolysis of proteins with broad specificity for peptide bonds.
            Preferentially cleaves -Arg-Arg+ bonds in small molecule
            substrates (thus differing from catheprin L).  In addition to
            being an endopeptidase, shows peptidyl-dipeptidase activity,
            liberating C-terminal dipeptides
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COMMENT     An intracellular (lysosomal) enzyme.
DISEASE     MIM: 116810  Cathepsin B
MOTIF       PS: PS00139  Q-x(3)-[GE]-x-C-[YW]-x(2)-[STAGC]-[STAGCV]
            PS: PS00639  [LIVMGSTAN]-x-H-[GSACE]-[LIVM]-x-[LIVMAT](2)-G-x-
                         [GSADNH]
            PS: PS00640  [FYCH]-[WI]-[LIVT]-x-[KRQAG]-N-[ST]-W-x(3)-[FYW]-G-
                         x(2)-G-[LFYW]-[LIVMFYG]-x-[LIVMF]
GENES       HSA: CTSB(Hs.84898)
STRUCTURES  PDB: 1CPJ  1CSB  1CTE  1HUC  1MIR  1THE  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.22.1
            WIT (What Is There) Metabolic Reconstruction: 3.4.22.1
            SCOP (Structural Classificaion of Proteins): 3.4.22.1
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