ENTRY       EC 3.4.21.72
NAME        IgA-specific serine endopeptidase
            IgA protease
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Cleavage of immunoglobulin A molecules at certain Pro+ bonds in
            the hinge region.  No small molecule substrates are known
            IgA protease
SUBSTRATE   Immunoglobulin A
            H2O
PRODUCT     Peptide
COMMENT     Species variants differing slightly in specificity are secreted by
            Gram negative bacteria Neisseria gonorrhoeae and Haemophilus
            influenzae.  Distant homologue of chymotrypsin. Some other
            bacterial endopeptidases with similar specificity are of
            metallo-type (see EC 3.4.24.13).
GENES       HIN: HI0990(IgA)
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.21.72
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.72
///