ENTRY       EC 3.4.21.71
NAME        Pancreatic elastase II
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Preferential cleavage: Leu+, Met+ and Phe+.  Hydrolyses elastin
SUBSTRATE   Elastin
            H2O
PRODUCT     Peptide
COMMENT     Formed by activation of proelastase II from mammlian pancreas by
            trypsin. Usually, only one of the pancreatic elastases (see also
            EC 3.4.21.36) is expressed in a given species; human pancreatic
            elastase is of type II.
DISEASE     MIM: 130130  Elastase-2, neutrophil
MOTIF       PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.21.71
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.71
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