ENTRY       EC 3.4.21.70
NAME        Pancreatic endopeptidase E
            Cholesterol-binding proteinase
            Elastase III
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Preferential cleavage: Ala+.  Does not hydrloyse elastin
SUBSTRATE   Peptide
            H2O
PRODUCT     Peptide
COMMENT     A homologue of chymotrypsin from pancreatic juice.  Unlike
            elastases, has an acidic pI.  Binds cholesterol.
MOTIF       PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.21.70
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.70
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