ENTRY       EC 3.4.21.7
NAME        Plasmin
            Fibrinase
            Fibrinolysin
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Preferential cleavage: Lys+ > Arg+; higher selectivity than
            trypsin.  Converts fibrin into soluble products
SUBSTRATE   Peptide(Lys-, Arg-)
            Peptide
            Fibrin
            Amide
            Ester
            H2O
PRODUCT     Amino acid
            Alcohol
COMMENT     Formed from plasminogen by proteolysis which results in multiple
            forms of the active plasmin. A homologue of chymotrypsin.
            Formerly EC 3.4.4.14.
DISEASE     MIM: 173350  Plasminogen; Plasminogen Tochigi disease (3);
                         Dysplasminogenemic thrombophilia (1); Plasminogen
                         deficiency, types I and II (1)
MOTIF       PS: PS00021  [FY]-C-R-N-P-[DNR]
            PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
STRUCTURES  PDB: 1CEA  1CEB  1HPJ  1HPK  1KRN  1PMK  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.21.7
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.7
            SCOP (Structural Classificaion of Proteins): 3.4.21.7
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