ENTRY       EC 3.4.21.66
NAME        Thermitase
            Thermophilic Streptomyces serine proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Hydrolysis of proteins, including collagen
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
INHIBITOR   P-Mercuribenzoate
COMMENT     A homologue of subtilisin from Thermoactinomyces vulgaris
            containing a single Cys, near the active site His, and inhibited
            by p-mercuribenzoate.  The N-terminal extension of the polypeptide
            chain relative to subtilisin contributes to Ca2+-binding and the
            high thermostability.  The amino acid composition and properties
            of the thermostable enzyme from Streptomyces rectus var.
            proteolyticus (formerly included in EC 3.4.21.14) are closely
            similar.
MOTIF       PS: PS00136  [STAIV]-x-[LIVMF]-[LIVM]-D-[DSTA]-G-[LIVMFC]-x(2,3)-
                         [DNH]
            PS: PS00137  H-G-[STM]-x-[VC]-[STAG]-[GS]-x-[LIVMA]-[STAGCLV]-[SAGM]
            PS: PS00138  G-T-S-x-[SA]-x-P-x(2)-[STAVC]-[AG]
STRUCTURES  PDB: 1THM  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.21.66
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.66
            SCOP (Structural Classificaion of Proteins): 3.4.21.66
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