ENTRY       EC 3.4.21.65
NAME        Thermomycolin
            Thermomycolase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Rather nonspecific hydrolysis of proteins.  Preferential cleavage:
            Ala+, Tyr+, Phe+ in small molecule substrates
SUBSTRATE   Peptide
            H2O
PRODUCT     Peptide
COMMENT     A homologue of subtilisin from the thermophilic fungus Malbranchea
            pulchella var.  sulfurea containing Cys, but knot inhibited by
            p-mercuribenzoate.  Very thermostable.  Formerly included in
            EC 3.4.21.14.
MOTIF       PS: PS00136  [STAIV]-x-[LIVMF]-[LIVM]-D-[DSTA]-G-[LIVMFC]-x(2,3)-
                         [DNH]
            PS: PS00137  H-G-[STM]-x-[VC]-[STAG]-[GS]-x-[LIVMA]-[STAGCLV]-[SAGM]
            PS: PS00138  G-T-S-x-[SA]-x-P-x(2)-[STAVC]-[AG]
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.21.65
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.65
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