ENTRY       EC 3.4.21.62
NAME        Subtilisin
            Subtilisin BPN'
            Subtilisin B
            Subtilopeptidase B
            Subtilopeptidase C
            Nagarse
            Nagarse proteinase
            Subtilisin Novo
            Bacterial proteinase Novo
            Subtilisin Carlsberg
            Subtilisin A
            Subtilopeptidase A
            Alcalase Novo
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Hydrolysis of proteins with broad specificity for peptide bonds,
            and a preference for a large uncharged residue in P1.  Hydrolyses
            peptide amide
SUBSTRATE   Peptide
            Protein
            H2O
PRODUCT     Peptide
            Protein
COMMENT     Subtilisin is a serine endopeptidase that evolved independently of
            chymotrypsin.  It contains no cysteine residues (although these
            are found in homologous enzymes).  Species variants include
            subtilisin BPN' (also subtilisin B, subtilopeptidase B,
            subtilopeptidase C, Nagarse, Nagarse proteinase, subtilisin Novo,
            bacterial proteinase Novo) and subtilisin Carlsberg (subtilisin A,
            subtilopeptidase A, alcalase Novo).  Formerly EC 3.4.4.16 and
            included in EC 3.4.21.14.  Similar enzymes are produced by various
            Bacillus subtilis strains and other Bacillus species.
MOTIF       PS: PS00136  [STAIV]-x-[LIVMF]-[LIVM]-D-[DSTA]-G-[LIVMFC]-x(2,3)-
                         [DNH]
            PS: PS00137  H-G-[STM]-x-[VC]-[STAG]-[GS]-x-[LIVMA]-[STAGCLV]-[SAGM]
            PS: PS00138  G-T-S-x-[SA]-x-P-x(2)-[STAVC]-[AG]
GENES       BSU: aprE(sprE)
STRUCTURES  PDB: 1SBN  1SCA  1SCB  1SCD  1SCN  1SIB  1SPB  1ST3  1SUD  1SUP  
                 1SVN  2SEC  1SBI  5SIC  1SUC  1SUB  1SBH  3SIC  1SBC  1MPT  
                 1CSE  1AF4  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.21.62
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.62
            SCOP (Structural Classificaion of Proteins): 3.4.21.62
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