ENTRY       EC 3.4.21.61
NAME        Kexin
            Yeast KEX2 protease
            Proteinase yscF
            Prohormone-processing endoprotease
            Paired-basic endopeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Cleavage of -Lys-Arg+ and Arg-Arg+ bonds to process yeast
            alpha-factor pheromone and killer toxin precursors
SUBSTRATE   Yeast alpha-factor pheromone
            Killer toxin precursor
            H2O
PRODUCT     Protein
            Peptide
INHIBITOR   P-Mercuribenzoate
COFACTOR    Calcium
COMMENT     A Ca2+-activated subtilisin homologue, containing Cys near the
            active site His, and inhibited by p-mercuribenzoate.  Similar
            enzymes occur in mammals.  Formerly EC 3.4.22.23.
MOTIF       PS: PS00136  [STAIV]-x-[LIVMF]-[LIVM]-D-[DSTA]-G-[LIVMFC]-x(2,3)-
                         [DNH]
            PS: PS00137  H-G-[STM]-x-[VC]-[STAG]-[GS]-x-[LIVMA]-[STAGCLV]-[SAGM]
            PS: PS00138  G-T-S-x-[SA]-x-P-x(2)-[STAVC]-[AG]
GENES       SCE: YNL238W(KEX2)
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.21.61
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.61
///