ENTRY       EC 3.4.21.6
NAME        Coagulation Factor Xa
            Thrombokinase
            Prothrombase
            Prothrombinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Selective cleavage of Arg+Thr and then Arg+Ile bonds in
            prothrombin to form thrombin
SUBSTRATE   Peptide
            Prothrombin
            Amide
            Ester
            H2O
PRODUCT     Amino acid
            Thrombin
            Alcohol
COMMENT     Formed from the proenzyme Factor X by limited proteolysis. A
            homologue of chymotrypsin. Scutelarin (EC 3.4.21.60) has similar
            specificity.
DISEASE     MIM: 227600  Coagulation factor X; Factor X deficiency (3)
MOTIF       PS: PS00011  x(12)-E-x(3)-E-x-C-x(6)-[DEN]-x-[LIVMFY]-x(9)-[FYW]
            PS: PS00022  C-x-C-x(5)-G-x(2)-C
            PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
GENES       HSA: F10
STRUCTURES  PDB: 1WHE  1WHF  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.21.6
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.6
///