ENTRY       EC 3.4.21.53
NAME        Endopeptidase La
            ATP-dependent serine proteinase
            Lon proteinase
            Protease La
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Hydrolysis of proteins in presence of ATP
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
INHIBITOR   Vanadate
COMMENT     Product of the lon gene, in E. coli. ATP hydrolysis is linked
            with peptide bond hydrolysis; vanadate inhibits both reactions.
            Not a homologue of chymotrypsin or subtilisin. A similar enzyme
            occurs in animal mitochondria.
MOTIF       PS: PS01046  D-G-[PD]-S-A-[GS]-[LIVMCA]-[TA]-[LIVM]
GENES       MJA: MJ1417
            MTH: MTH785 MTH892
            ECO: b0439(lon)
            HIN: HI0462(lon)
            HPY: HP1379
            BSU: lonA(lon)
            MGE: MG239(lon)
            MPN: F10_orf795(lon)
            SYN: lon) sll0195(ECOLI_423
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.21.53
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.53
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