ENTRY       EC 3.4.21.5
NAME        Thrombin
            Fibrinogenase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Selective cleavage of Arg+Gly bonds in fibrinogen to form fibrin
            and release fibrinopeptides A and B
SUBSTRATE   Peptide
            Fibrinogen
            Amide
            Ester
            H2O
PRODUCT     Amino acid(Arg-)
            Fibrin
            Alcohol
            Fibrinopeptide A
            Fibrinopeptide B
INHIBITOR   Benzamidine
            D-Phe-Pro-Arg-CH2Cl
            Nalpha-(2-naphthyl-sulfonyl-glycyl)-D-para-amidinopheyl-
            $alanylpiperadine
            (2R,4R)-4-Methyl-1[Nalpha-[(3-methyl-1,2,3,4-tetrahydro-
            $8-quinolinyl)sulfonyl]-L-arginyl)]-2-
            $piperadinecarboxylic acid
COMMENT     Formed from prothrombin.  More selective than trypsin and plasmin.
            A homologue of chymotrypsin.  Formerly EC 3.4.4.13.
            Inhibitors: J.Biol.Chem.266,20085-20093(1991)
DISEASE     MIM: 176930  Coagulation factor II (thrombin); Hypoprothrombinemia
                         (3); Dysprothrombinemia (3)
MOTIF       PS: PS00011  x(12)-E-x(3)-E-x-C-x(6)-[DEN]-x-[LIVMFY]-x(9)-[FYW]
            PS: PS00021  [FY]-C-R-N-P-[DNR]
            PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
GENES       HSA: F2
STRUCTURES  PDB: 1IHS  1HXF  1HXE  1HUT  1HRT  4HTC  1HDT  1HAP  1HAO  1HAI  
                 1HAH  1HAG  1FPH  1HBT  1FPC  1ETS  1ETR  1DWE  1DWD  1DWC  
                 1DWB  1DIT  1BMN  1BMM  1BBR  1AHT  1ABJ  1ABI  1IHT  1LHC  
                 1LHD  1LHE  1LHF  1LHG  1MKW  1MKX  1NRN  1NRO  1NRP  1NRQ  
                 1NRR  1NRS  1PPB  1TBQ  1TBR  1THR  1THS  1TMB  1TMT  1TMU  
                 1TOM  1UCY  1UMA  1VIT  2HGT  2HPP  2HPQ  2SPT  3HAT  1HGT  
                 1ETT  3HTC  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.21.5
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.5
            SCOP (Structural Classificaion of Proteins): 3.4.21.5
///