ENTRY       EC 3.4.21.48
NAME        Cerevisin
            Yeast proteinase B
            Proteinase yscB
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Hydrolysis of proteins with broad specificity, and of
            Bz-Arg-OEt > Ac-Tyr-OEt. Does not hydrolyse peptide amides
SUBSTRATE   Bz-Arg-OEt
            Ac-Tyr-OEt
            H2O
PRODUCT     Arg-OEt
            Tyr-OEt
INHIBITOR   Diisopropyl fluorophosphate
            P-Chloromercuribenzoate
            Hg
COMMENT     From Saccharomyces cerevisiae (baker's yeast, brewer's yeast).
            Homologue of subtilisin, but contains a Cys residue near the
            active site His, and is inhibited by mercurials.  Proteinase ycaB
            is a similar enzyme from the yeast Candida albicans.
MOTIF       PS: PS00136  [STAIV]-x-[LIVMF]-[LIVM]-D-[DSTA]-G-[LIVMFC]-x(2,3)-
                         [DNH]
            PS: PS00137  H-G-[STM]-x-[VC]-[STAG]-[GS]-x-[LIVMA]-[STAGCLV]-[SAGM]
            PS: PS00138  G-T-S-x-[SA]-x-P-x(2)-[STAVC]-[AG]
GENES       SCE: YEL060C(PRB1)
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.21.48
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.48
///