ENTRY       EC 3.4.21.46
NAME        Complement Factor D
            C3 proactivator convertase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Selective cleavage of Arg+Lys bond in complement Factor B when in
            complex with complement subcomponent C3b or with cobra venom
            factor
SUBSTRATE   Complement factor B
            Complement component C3b
            Cobra venom factor
            H2O
PRODUCT     C3 convertase
COMMENT     A component of the alternative pathway of complement activation.
            This reaction is analogous to the activation of complement
            component C2 by complement subsomponent C1s-.
MOTIF       PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
STRUCTURES  PDB: 1DST  1DSU  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.21.46
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.46
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