ENTRY       EC 3.4.21.4
NAME        Trypsin
            Cocoonase
            Streptomyces griseus trypsin
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Preferential cleavage: Arg+, Lys+
SUBSTRATE   Peptide
            Amide
            Ester
            H2O
PRODUCT     Amino acid(Arg-, Lys-)
            Alcohol
INHIBITOR   Tos-Arg-CH2Cl
            Tos-Lys-CH2Cl
COMMENT     The single polypeptide chain cattle beta-trypsin is formed from
            trypsinogen by cheavage of one peptide bond.  Further peptide
            bond cleavages produce alpha and other iso-forms.  Isolated as
            multiple cationic and anionic trypsins from the pancreas of many
            vertebrates and from lower species including crayfish, insects
            (cocoonase) and microorganisms (Streptomyces griseus trypsin).
            Formerly EC 3.4.4.4.
DISEASE     MIM: 276000  Protease, serine, 1 (trypsin 1); Trypsinogen
                         deficiency (1); Pancreatitis, hereditary, 167800 (3)
            MIM: 601564  Protease, serine, 2 (trypsin-2)
MOTIF       PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
GENES       HSA: PRSS1(TRY1)
STRUCTURES  PDB: 1TNH  1SGT  2PTN  2PTC  1TRY  1TRN  1TRM  1TPP  1TPO  1TPA  
                 1TNL  1TNK  1TNJ  1TNI  1TNG  1TLD  1TAW  1TAB  1SMF  1SLX  
                 1SLW  1SLU  1PPH  1PPE  1PPC  1NTP  1MCT  1MAY  1MAX  1JRT  
                 1JRS  1GBT  1EPT  1DPO  1BTZ  1BTY  1BTX  1BTW  1BTP  1BRC  
                 1BRB  1BRA  1ANE  1AND  1ANC  1ANB  1AKS  2TBS  2TLD  2TRM  
                 3PTB  3PTN  5PTP  1SLV  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.21.4
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.4
            SCOP (Structural Classificaion of Proteins): 3.4.21.4
///