ENTRY       EC 3.4.21.39
NAME        Chymase
            Mast cell protease I
            Skeletal muscle protease
            Skin chymotryptic proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Preferential cleavage: Phe+ > Tyr+ > Trp+ > Leu+
SUBSTRATE   Peptide
            H2O
PRODUCT     Oligopeptide
            Peptide
COMMENT     In mast cell granules.  A homologue of chymotrypsin.
DISEASE     MIM: 118940  Chymase-1, mast cell
MOTIF       PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
GENES       HSA: CMA1
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.21.39
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.39
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