ENTRY       EC 3.4.21.38
NAME        Coagulation Factor XIIa
            Hageman Factor (activated)
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Selective cleavage of Arg+Ile bonds in Factor VII to form Factor
            VIIa and Factor XI to form Factor XIa
SUBSTRATE   Coagulation Factor VII
            Coagulation Factor XI
            Coagulation Factor XII
            Plasminogen
            Prokallikrein
            H2O
PRODUCT     Coagulation Factor VIIa
            Coagulation Factor XIa
            Coagulation Factor XIIa
            Plasmin
            Kallikrein
COMMENT     Also activates plasminogen and plasma prokallikrein.  Formed from
            the proenzyme, Factor XII, by plasma kallikrein or Factor XIIa.  A
            homologue of chymotrypsin.
DISEASE     MIM: 234000  Coagulation factor XII (Hageman factor); Factor XII
                         deficiency (3)
MOTIF       PS: PS00021  [FY]-C-R-N-P-[DNR]
            PS: PS00022  C-x-C-x(5)-G-x(2)-C
            PS: PS00023  C-x(2)-P-F-x-[FYW]-x(7)-C-x(8,10)-W-C-x(4)-[DNS]-[FYW]-
                         x(3,5)-[FYW]-x-[FYW]-C
            PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
GENES       HSA: F12(Hs.1321)
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.21.38
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.38
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