ENTRY       EC 3.4.21.37
NAME        Leukocyte elastase
            Lysosomal elastase
            Neutrophil elastase
            Polymorphonuclear leukocyte elastase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Hydrolysis of proteins, including elastin.  Preferential cleavage:
            Val+ > Ala+
SUBSTRATE   Protein
            Peptide
            H2O
            Elastin
PRODUCT     Oligopeptide
            Protein
            Peptide
COMMENT     Differs from pancreatic elastase in specificity on synthetic
            substrates and in inhibitor sensitivity.  A homologue of
            chymotrypsin.  Formerly included in EC 3.4.21.11.
MOTIF       PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
GENES       HSA: ELA2(Hs.99863)
STRUCTURES  PDB: 1HNE  1PPF  1PPG  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.21.37
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.37
            SCOP (Structural Classificaion of Proteins): 3.4.21.37
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