ENTRY       EC 3.4.21.36
NAME        Pancreatic elastase
            Pancreatopeptidase E
            Pancreatic elastase I
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Hydrolysis of proteins, including elastin.  Preferential cleavage:
            Ala+
SUBSTRATE   Protein
            Peptide
            Elastin
            H2O
PRODUCT     Oligopeptide
            Protein
            Peptide
COMMENT     Formed by activation of proelastase from mammalian pancreas by
            trypsin.  A homologue of chymotrypsin.  Formerly included in
            EC 3.4.21.11.
DISEASE     MIM: 130120  Elastase-1
MOTIF       PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
GENES       HSA: ELA1(Hs.21)
STRUCTURES  PDB: 1BMA  1EAS  1EAT  1EAU  1ELA  1ELB  1ELC  1ELD  1ELE  1ELF  
                 1ELG  1ELT  1ESA  1ESB  1FLE  1INC  1JIM  1LVY  1NES  9EST  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.21.36
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.36
            SCOP (Structural Classificaion of Proteins): 3.4.21.36
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