ENTRY       EC 3.4.21.35
NAME        Tissue kallikrein
            Glandular kallikrein
            Pancreatic kallikrein
            Submandibular kallikrein
            Submaxillary kallikrein
            Kidney kallikrein
            Urinary kallikrein
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Preferential cleavege of Arg+ bonds in small molecule substrates.
            Highly selective action to release kallidin (lysyl-bradykinin)
            from kininogen involves hydrolysis of Met+ or Leu+. The rat enzyme
            is unusual in liberating bradykinin directly from autologous
            kininogens by cleavage at two Arg+ bonds
SUBSTRATE   Kininogen
            H2O
PRODUCT     Lysyl-bradykinin
            Kallidin
            Bradykinin
COMMENT     Formed from tissue prokallikrein by activation with trypsin.  A
            homologue of chymotrypsin.  Formerly EC 3.4.4.21 and included in
            3.4.21.8.  A large number of tissue kallikrein-related sequences
            have been reported for rats and mice, though fewer
            seem to exist in other mammals.  The few that have been isolated
            and tested on substrates include mouse gamma-renin (EC 3.4.21.54),
            submandibular proteinase A (formerly EC 3.4.21.40, 142, 430),
            epidermal growth-factor-binding protein, nerve growth factor
            gamma-subunit, rat tonin, submaxillary proteinases A and B,
            T-kininogenase, kallikreins k7 and k8 and human
            prostate-specific antigen (gamma-seminoprotein).
DISEASE     MIM: 147910  Kallikrein, renal/pancreas/salivary
            MIM: 147960  Kallikrein-2, prostatic
MOTIF       PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
GENES       HSA: KLK1(Hs.73098) KLK2
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.21.35
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.35
///