ENTRY       EC 3.4.21.32
NAME        Barchyurin
            Uca pugilator collagenolytic proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Hydrolysis of proteins, with broad specificity for peptide bonds.
            Native collagen is cleaved about 751436424f the length of the molecule
            from the N-terminus.  Low activity on small molecule substrates of
            both trypsin and chymotrypsin.
SUBSTRATE   Collagen
            H2O
            Protein
            Peptide
PRODUCT     Protein
            Peptide
INHIBITOR   Tos-Lys-CH2Cl
COMMENT     From hepatopancreas of the fiddler crab, Uca pugilator. A
            homologue of chymotrypsin.  Other serine endopeptidases that
            degrade collagen, but are not listed separately here, include a
            second endopeptidases from Uca pugilator, digestive enzymes
            from other decapod crustacea, and an enzyme from the fungus
            Entomophthora (formerly EC 3.4.21.33).
MOTIF       PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.21.32
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.32
///