ENTRY       EC 3.4.21.27
NAME        Coagulation Factor XIa
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Selective cleavage of Arg+Ala and Arg+Val bonds in Factor IX to
            form Factor IXa
SUBSTRATE   Coagulation Factor IX
            H2O
PRODUCT     Coagulation Factor IXa
COMMENT     A homologue of chymotrypsin, and one of the gamma-carboxyglutamic
            acid-containing blood coagulation factors.  The proenzyme
            Factor XI is activated by Factor XIIa.
DISEASE     MIM: 264900  Coagulation factor XI (plasma thromboplastin
                         antecedent); Factor XI deficiency (3)
MOTIF       PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
            PS: PS00495  C-x(3)-[LIVMFY]-x(5)-[LIVMFY]-x(3)-[DENQ]-[LIVMFY]-
                         x(10)-C-x(3)-C-T-x(4)-C-x-[LIVMFY]-F-x-[FY]-x(13,14)-C-
                         x-[LIVMFY]-[RK]-x-[ST]-x(14,15)-S-G-x-[ST]-[LIVMFY]-
                         x(2)-C
GENES       HSA: F11(FXI)
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.21.27
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.27
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