ENTRY       EC 3.4.21.26
NAME        Prolyl oligopeptidase
            Post-proline cleaving enzyme
            Proline-specific endopeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Hydrolysis of Pro+ >> Ala+ in oligopeptides
SUBSTRATE   Oligopeptide
            Peptide
            H2O
            Oxytocin
            Vasopressin
PRODUCT     Oligopeptide
            Peptide
EFFECTOR    Thiol compound
COMMENT     Found in vertebrates, plants and Flavobacterium.  Generally
            cytosolic, commonly activated by thiol compounds.  Not homologous
            with chymotrypsin or subtilisin.
DISEASE     MIM: 600400  Prolyl endopeptidase
MOTIF       PS: PS00708  D-x(3)-A-x(3)-[LIVMFYW]-x(14)-G-x-S-x-G-G-[LIVMFYW](2)
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.21.26
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.26
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