ENTRY       EC 3.4.21.22
NAME        Coagulation Factor IXa
            Activated Christmas Factor
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Selective cleavage of Arg+Ile bond in Factor X to form Factor Xa
SUBSTRATE   Coagulation Factor X
            H2O
PRODUCT     Coagulation Factor Xa
COMMENT     A chymotrypsin homologue, and one of the gamma-carboxyglutamic
            acid-containing blood coagulation factors.  The proenzyme Factor
            IX is activated by Factor XIa.
DISEASE     MIM: 306900  Coagulation factor IX (plasma thromboplastic
                         component); Hemophilia B (3)
MOTIF       PS: PS00011  x(12)-E-x(3)-E-x-C-x(6)-[DEN]-x-[LIVMFY]-x(9)-[FYW]
            PS: PS00022  C-x-C-x(5)-G-x(2)-C
            PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
GENES       HSA: F9(FIX)
STRUCTURES  PDB: 1CFI  1MGX  1PFX  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.21.22
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.22
///