ENTRY       EC 3.4.21.21
NAME        Coagulation Factor VIIa
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Selective cleavage of Arg+Ile bond in Factor X to form Factor Xa
SUBSTRATE   Coagulation Factor X
            H2O
PRODUCT     Coagulation Factor Xa
INHIBITOR   Diisopropyl fluorophosphate
COMMENT     Formed from the precursor Factor VII.  The cattle enzyme is more
            readily inhibited by diisopropyl fluorophosphate than the human.
DISEASE     MIM: 227500  Coagulation factor VII; Factor VII deficiency (3)
MOTIF       PS: PS00011  x(12)-E-x(3)-E-x-C-x(6)-[DEN]-x-[LIVMFY]-x(9)-[FYW]
            PS: PS00022  C-x-C-x(5)-G-x(2)-C
            PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.21.21
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.21
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