ENTRY       EC 3.4.21.10
NAME        Acrosin
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Preferential cleavage: Arg+, Lys+
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Amino acid
INHIBITOR   Tripsin inhibitor
COMMENT     Occurs in spermatozoa; formed from proacrosin by limited
            proteolysis. Inhibited by naturally occurring tripsin inhibitors.
DISEASE     MIM: 102480  Acrosin; ?Male infertility due to acrosin deficiency
                         (2)
MOTIF       PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
GENES       HSA: ACR(acrosin)
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.21.10
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.10
///