ENTRY       EC 3.4.21.1
NAME        Chymotrypsin
            Chymotrypsin A
            Chymotrypsin B
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Preferential cleavage: Tyr+, Trp+, Phe+, Leu+
SUBSTRATE   Peptide
            Amide
            Ester
            H2O
PRODUCT     Amino acid(Tyr-, Trp-, Phe-, Leu-)
            Alcohol
INHIBITOR   Tos-Phe-CH2Cl
COMMENT     Chymotrypsin A is formed from cattle and pig chymotrypsinogen A,
            several iso-forms being produced according to the number of bonds
            hydrolysed in the precursor.  Formerly EC 3.4.4.5.  Chymotrypsin
            B, formerly EC 3.4.4.6, formed from chymotrypsinogen B, is
            homologous with chymotrypsin A.  Enzymes with specificity similar
            to that of chymotrypsins A and B have been isolated from many
            species.
DISEASE     MIM: 118890  Chymotrypsinogen B
MOTIF       PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
GENES       HSA: CTRB1(CTRB)
STRUCTURES  PDB: 0GCB  1ACB  1CHO  1GCD  1GCT  1GHA  1GHB  1GMC  1GMD  1GMH  
                 1MTN  2CHA  2GCH  2GCT  2GMT  3GCH  3GCT  4CHA  4GCH  5CHA  
                 5GCH  6CHA  6GCH  7GCH  8GCH  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.21.1
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.1
            SCOP (Structural Classificaion of Proteins): 3.4.21.1
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