ENTRY       EC 3.4.19.8
NAME        Pteroylpoly-gamma-glutamate carboxypeptidase
            Microsomal gamma-glutamyl carboxypeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Omega peptidases
REACTION    Removal of a gamma-glutamyl residue from the unsubstituted
            C-terminus of pteroylpoly-gamma-glutamate
SUBSTRATE   Pteroylpoly-gamma-glutamate
            H2O
PRODUCT     Glutamate
            Folic acid
EFFECTOR    Metal
COMMENT     A high Mr, membrane-bound, brush-border exopeptidase.
            Sequentially removes gamma-glutamyl residues from pteroylpoly-
            gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and
            free glutamic acid. Requires the presence of a pteroyl N-terminus.
            Shows no thiol dependence, but is metal dependent.
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.19.8
            WIT (What Is There) Metabolic Reconstruction: 3.4.19.8
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