ENTRY       EC 3.4.19.6
NAME        Pyroglutamyl-peptidase II
            Thyroliberinase
            Pyroglutamyl aminopeptidase II
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Omega peptidases
REACTION    Release of the N-terminal pyroglutamyl group from pGlu+His-Xaa
            tripeptides and pGlu+His-Xaa-Gly tetrapeptides
SUBSTRATE   PyroGlu-His-Xaa
            PyroGlu-His-Xaa-Gly
            H2O
            Thyrotropin releasing hormone
PRODUCT     Pyroglutamate
INHIBITOR   Metal chelator
COMMENT     Highly specific for thyrotropin releasing hormone (pyroglutamyl-
            histidyl-prolylamide).  Will not cleave the pyroglutamyl-histidyl
            bond of luteinizing hormone releasing hormone.  Found in serum and
            brain.  Inhibited by metal chelators.
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.19.6
            WIT (What Is There) Metabolic Reconstruction: 3.4.19.6
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