ENTRY       EC 3.4.19.3
NAME        Pyroglutamyl-peptidase I
            5-Oxoprolyl-peptidase
            Pyrrolidone-carboxylate peptidase
            Pyroglutamyl aminopeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Omega peptidases
REACTION    Release of an N-terminal pyroglutamyl group from a polypeptide,
            provided the next residue is not proline
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
INHIBITOR   Thiol-blocking reagent
COMMENT     Inhibited by thiol-blocking reagents.  Occurs in mammalian
            tissues, microorganisms and plants.  Formerly EC 3.4.11.8.
GENES       BSU: pcp
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.19.3
            WIT (What Is There) Metabolic Reconstruction: 3.4.19.3
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