ENTRY       EC 3.4.19.2
NAME        Peptidyl-glycinamidase
            Carboxyamidase
            Peptidyl carboxyamidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Omega peptidases
REACTION    Cleavage of C-terminal glycinamide from polypeptides
SUBSTRATE   Peptide
            H2O
PRODUCT     Glycine
            Peptide
INHIBITOR   Diisopropyl fluorophosphate
COMMENT     Inactivates vasopressin and oxytocin by splitting off glycinamide.
            Also cleaves ester substrates of trypsin and chymotrypsin.
            Although glycinamide is by far the preferred cleaving group, other
            aminoacylamides may also be released, e.g. phenylalaninamide. The
            toad skin enzyme is inhibited by diisopropyl fluorophosphate.
            Formerly EC 3.4.15.2.
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.19.2
            WIT (What Is There) Metabolic Reconstruction: 3.4.19.2
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