ENTRY       EC 3.4.19.1
NAME        Acylaminoacyl-peptidase
            Acylamino-acid-releasing enzyme
            N-Acylpeptide hydrolase
            N-Formylmethionine (fMet) aminopeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Omega peptidases
REACTION    Cleavege of an N-acetyl or N-formyl amino acid from the N-terminus
            of a polypeptide
SUBSTRATE   Acylaminoacyl-peptide
            H2O
            Glycyl-peptide
PRODUCT     N-Acetyl amino acid
            N-Formyl amino acid
            Peptide
            Glycyl amino acid
INHIBITOR   Diisopropyl fluorophosphate
COMMENT     Active at neutral pH. Several variants of this enzyme exist; the
            human erythrocyte enzyme is relatively specific for removal of
            N-acetylalanine from peptides. Displays dipeptidyl-peptidase
            activity on glycyl-peptides, perhaps as a result of mis-
            recognition of the glycyl residue as an uncharged N-acyl group.
            Inhibited by diisopropyl fluorophosphate. Formerly EC 3.4.14.3.
DISEASE     MIM: 102645  N-acylaminoacyl-peptide hydrolase
MOTIF       PS: PS00708  D-x(3)-A-x(3)-[LIVMFYW]-x(14)-G-x-S-x-G-G-[LIVMFYW](2)
GENES       HSA: APEH(D3S48E)
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.19.1
            WIT (What Is There) Metabolic Reconstruction: 3.4.19.1
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