ENTRY       EC 3.4.17.3
NAME        Lysine carboxypeptidase
            Carboxypeptidase N
            Arginine carboxypeptidase
            Kininase I
            Anaphylatoxin inactivator
            Plasma carboxypeptidase B
            Creatine kinase conversion factor
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metallocarboxypeptidases
REACTION    Release of a C-terminal basic amino acid, preferentially lysine
SUBSTRATE   Peptidyl-L-lysine
            Peptidyl-L-arginine
            H2O
            Peptide
            Bradykinin
            Anaphylatoxin
PRODUCT     Peptide
            L-Lysine
            L-Arginine
            Inactivated bradykinin
            Inactivated anaphylatoxin
COFACTOR    Zinc
COMMENT     A zinc enzyme found in plasma. Inactivates bradykinin and
            anaphylatoxins in blood plasma. Formerly EC 3.4.12.7.
DISEASE     MIM: 212070  Carboxypeptidase B2 (plasma)
MOTIF       PS: PS00132  [PK]-x-[LIVMFY]-x-[LIVMFY]-x(4)-H-[STAG]-x-E-x-[LIVM]-
                         [STAG]-x(6)-[LIVMFYTA]
            PS: PS00133  H-[STAG]-x(3)-[LIVME]-x(2)-[LIVMFYW]-P-[FYW]
GENES       HSA: ACBP(Hs.2246)
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.17.3
            WIT (What Is There) Metabolic Reconstruction: 3.4.17.3
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