ENTRY       EC 3.4.17.2
NAME        Carboxypeptidase B
            Protaminase
            Pancreatic carboxypeptidase B
            Tissue carboxypeptidase B
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metallocarboxypeptidases
REACTION    Preferential release of a C-terminal lysine or arginine amino acid
SUBSTRATE   Peptidyl-L-lysine
            Peptidyl-L-arginine
            Peptide
            H2O
PRODUCT     Peptide
            L-Lysine
            L-Arginine
COFACTOR    Zinc
COMMENT     A zinc enzyme formed from procarboxypeptidase B. Isolated from
            cattle, pig and dogfish pancreas and other sources, including skin
            fibroblasts and adrenal medulla. Formerly EC 3.4.2.2 and 3.4.12.3.
MOTIF       PS: PS00132  [PK]-x-[LIVMFY]-x-[LIVMFY]-x(4)-H-[STAG]-x-E-x-[LIVM]-
                         [STAG]-x(6)-[LIVMFYTA]
            PS: PS00133  H-[STAG]-x(3)-[LIVME]-x(2)-[LIVMFYW]-P-[FYW]
STRUCTURES  PDB: 1PBA  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.17.2
            WIT (What Is There) Metabolic Reconstruction: 3.4.17.2
            SCOP (Structural Classificaion of Proteins): 3.4.17.2
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