ENTRY       EC 3.4.17.13
NAME        Muramoyltetrapeptide carboxypeptidase
            Carboxypeptidase IIW
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metallocarboxypeptidases
REACTION    Hydrolysis of the bond: N-acetyl-D-glucosaminyl-N-acetylmuramoyl-
            -L-Ala-D-glutamyl-6-carboxy-L-lysyl+D-alanine
SUBSTRATE   N-Acetyl-D-glucosaminyl-N-acetylmuramoyl-L-Ala-D-glutamyl-6-
            $carboxy-L-lysyl-D-alanine
            H2O
PRODUCT     N-Acetyl-D-glucosaminyl-N-acetylmuramoyl-L-Ala-D-glutamyl-6-
            $carboxy-L-lysine
            D-Alanine
INHIBITOR   Thiol-blocking reagent
EFFECTOR    Manganese
            Calcium
COMMENT     Variants are known from various microorganisms. Involved in
            peptidoglycan synthesis, catalysing both decarboxylation and
            transpeptidation. Stimulated by divalent cations such as Mg2+
            and Ca2+, but not by Zn2+. Inhibited by thiol-blocking reagents,
            but unaffected by penicillin.
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.17.13
            WIT (What Is There) Metabolic Reconstruction: 3.4.17.13
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