ENTRY       EC 3.4.17.12
NAME        Carboxypeptidase M
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metallocarboxypeptidases
REACTION    Cleavage of C-terminal arginine or lysine residues from
            polypeptides.
SUBSTRATE   Peptide
            H2O
PRODUCT     L-Arginine
            L-Lysine
            Peptide
COMMENT     A mambrane-bound enzyme optimally active at neutral pH.
            Distinct from EC 3.4.17.2, 3.4.17.3 and 3.4.17.10.
DISEASE     MIM: 114860  Carboxypeptidase M
MOTIF       PS: PS00132  [PK]-x-[LIVMFY]-x-[LIVMFY]-x(4)-H-[STAG]-x-E-x-[LIVM]-
                         [STAG]-x(6)-[LIVMFYTA]
            PS: PS00133  H-[STAG]-x(3)-[LIVME]-x(2)-[LIVMFYW]-P-[FYW]
GENES       HSA: CPM(Hs.50997)
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.17.12
            WIT (What Is There) Metabolic Reconstruction: 3.4.17.12
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