ENTRY       EC 3.4.17.11
NAME        Glutamate carboxypeptidase
            Carboxypeptidase G
            Carboxypeptidase G1
            Carboxypeptidase G2
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metallocarboxypeptidases
REACTION    Release of C-terminal glutamate residues from a wide range of
            N-acylating moieties, including peptidyl, aminoacyl, benzoyl,
            benzyloxycarbonyl, folyl and pteroyl groups.
SUBSTRATE   Peptide
            H2O
PRODUCT     L-Glutamate
            Peptide
COFACTOR    Zinc
COMMENT     A zinc enzyme produced by pseudomonads, Flavobacterium sp. and
            Acinetobacter sp. Its ability to hydrolyse pteroyl-L-glutamate
            (folic acid) has led to its use as a folate-depleting,
            antitumour agent.
MOTIF       PS: PS00758  [LI]-[GAL]-[LIVMF]-x-[GSA]-H-x-D-[TV]-[STAV]
            PS: PS00759  [GSTAI]-[SANQ]-D-x-K-[GSACN]-x(2)-[LIVMA]-x(2)-
                         [LIVMFY]-x(14,17)-[LIVM]-x-[LIVMF]-[LIVMSTAG]-[LIVMFA]-
                         x(2)-[DN]-E-E-x-[GSTN]
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.17.11
            WIT (What Is There) Metabolic Reconstruction: 3.4.17.11
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