ENTRY       EC 3.4.17.10
NAME        Carboxypeptidase H
            Carboxypeptidase E
            Enkephalin convertase
            Cobalt-stimulated chromaffin granule carboxypeptidase
            Insulin granule-associated carboxypeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metallocarboxypeptidases
REACTION    Release of C-terminal arginine or lysine residues from
            polypeptide
SUBSTRATE   Peptidyl-L-lysine
            Peptidyl-L-arginine
            Peptide
            H2O
PRODUCT     Peptide
            L-Lysine
            L-Arginine
INHIBITOR   1,10-Phenanthroline
            Chelating agents
COFACTOR    Zinc
EFFECTOR    Cobalt
COMMENT     A zinc enzyme, activated by Co2+. Inhibited by 1,10-
            phenanthroline and other chelating agents. pH optimum 5.6.
            Located in storage granules of secretory cells, and active in
            processing of protein hormones and bioactive peptides. Distinct
            from EC 3.4.17.2 and 3.4.17.3.
MOTIF       PS: PS00132  [PK]-x-[LIVMFY]-x-[LIVMFY]-x(4)-H-[STAG]-x-E-x-[LIVM]-
                         [STAG]-x(6)-[LIVMFYTA]
            PS: PS00133  H-[STAG]-x(3)-[LIVME]-x(2)-[LIVMFYW]-P-[FYW]
GENES       HSA: CPE(Hs.75360)
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.17.10
            WIT (What Is There) Metabolic Reconstruction: 3.4.17.10
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