ENTRY       EC 3.4.17.1
NAME        Carboxypeptidase A
            Carboxypolypeptidase
            Pancreatic carboxypeptidase A
            Tissue carboxypeptidase A
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metallocarboxypeptidases
REACTION    Release of a C-terminal amino acid, but little or no action with
            -Asp, -Glu, -Arg, -Lys or -Pro
SUBSTRATE   Peptide
            H2O
PRODUCT     Peptide
            Amino acid
COFACTOR    Zinc
COMMENT     A zinc enzyme formed from procarboxypeptidase A. Isolated from
            cattle, pig and dogfish pancreas, and other sources including mast
            cells and skeletal muscle. Formerly EC 3.4.2.1 and 3.4.12.2.
DISEASE     MIM: 114850  Carboxypeptidase A
MOTIF       PS: PS00132  [PK]-x-[LIVMFY]-x-[LIVMFY]-x(4)-H-[STAG]-x-E-x-[LIVM]-
                         [STAG]-x(6)-[LIVMFYTA]
            PS: PS00133  H-[STAG]-x(3)-[LIVME]-x(2)-[LIVMFYW]-P-[FYW]
GENES       HSA: CPA1(CPA) CPA3(Hs.646)
STRUCTURES  PDB: 0CPS  1ARL  1ARM  1BAV  1CBX  1CPS  1PYT  1YME  2CTB  2CTC  
                 3CPA  4CPA  5CPA  6CPA  7CPA  8CPA  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.17.1
            WIT (What Is There) Metabolic Reconstruction: 3.4.17.1
            SCOP (Structural Classificaion of Proteins): 3.4.17.1
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